Doohickie is a faster rider than I am; and I live near his house and used to commute to the same office building 6 months ago. On a good day I could average 85 minutes each way. At first it would take me 105-120 minutes each way.
The route includes walking the bike over 50 yards of unpaved large gravel to cross train tracks; sometimes waiting on the train; waiting on some really slow crossings of busy highways and major arterials (at least 5); some decent grade long hill climbs; a low-water crossing and segment on a MUP where low speeds are required for safety; a school zone where rolling through stops is likely to get you ticketed.
Public transportation is not available anywhere near his new workplace and is much slower than riding the bike for the areas where the buses do run. However, there are several viable options for a park+ride strategy; there is a hospital 6 miles from his house with plentiful free parking and a security patrol; and there is a gated company recreation area 9 miles from his house. Both are right on his route and are safe places to leave the car. When I started bike commuting I would drive partway and then ride from one of these sites; and just do the full commute once/week. It really doesn't save that much time for an experienced cyclist and there will also be the times when you discover that you forgot something important when you transition from car to bike. For me that would be forgetting the bike headlights or gloves in cold weather.
The longer rides do have additional considerations. Time is one. Better lighting is needed. Warmer clothing for winter due to additional time in the cold. Bigger water bottles with better insulation for summer. Cycling-specific clothing may be more important. And determination to ride vs drive may be more conservative when conditions look iffy. Weather forecasts here aren't the greatest. There are some long rural stretches where it would be difficult to find shelter or assistance. So it can be tough balancing between being prepared and having to lug around non-essential stuff for the longer ride.