Clipless always. I have MTB shoes/pedals with SPD cleats and I keep "normal" shoes at work. I got the MTB setup for my road bike so the shoes would have good traction and be reasonably comfortable when walking. Great for commuting, errands, touring, and "destination" bike rides.
I feel much more secure on the pedals with the clipless pedals especially when standing.
Toeclips tore up many pair of shoes both on the sole and toe box. When riding without clipless / toeclips, I slipped too much on the rattrap pedals with some injuries.
It did not take long at all to get where it's second nature to clip in/out. There are plenty of stops on my commute so I get lots of practice.