When I was experimenting with saddle position and bar drop, I got saddle sores. (I'd not had trouble before with them. Saddle was too high and too far back.) Made small changes to eventually arrive at the place that was right. I.e., saddle sores went away ... for the most part, and leg extension/knee-over-spindle was within reason. I'd look at your fit there first.

In my thankfully limited experience with saddle sores, zit-like sores are different than abrasion sores, although I've had what began as an abrasion develop into a zit-like thing. The zit sores develop from a hair follicle that gets infected, caused by excessive friction. Chamois cream. Every ride for me.