Right now I have a stack of stems, maybe 4-5 all different lengths and angles, I also have at least 3 different seatposts. I have a Thomson setback(or set forward depending how you orient it) and a couple FSAs. I keep playing around with stuff, but to get the best fit I could so far on my bike I have to run a Thomson 410 pretty far out. I did a triathlon on my current bike just to say I had done it, so I got some clamp on aero bars and used the Thomson as a forward offset to get the geometry right, went through and fit myself on a trainer, etc, etc. But it's going to mainly be a road bike, that's what all my riding will be.
I can handle a fair amount of drop, I don't mind the saddle being well above the handlebars. I read up on a number of the different fit techniques, I have the plumb bobs and the levels, I end up getting my bikes set up...eh, so so considering what I have to work with. But with my weight I am wondering if running on the more extreme ends of "tweaking" the fit I am ultimately defeating the design of the frame. One guy I ride with suggested that running that much seat post may be adding too much stress to the frame at the seat tube/top tube joint.