Well, I put in about 14 miles on this setup on my commute yesterday. All in all, it went pretty well. The stuff sack mounted to the seat did start loosening itself. I think for a full day of riding, I'll tie the loose ends together to prevent slippage. Also, the bag on front tended to shift, so I'll have to be more careful about mounting it next time, making sure the straps are evenly spaced and cinched down tightly. I also managed to pick up one of those small bags that mount just behind the steerer on top of the top tube. I was able to put my gels, bars and tools in there, so that took another pound off of the pack and onto the bike. But in the end, that really only offsets the paperback I forgot to add to my list.
All in all, I think it will work out pretty well, but we'll find out for sure next week. I'll probably leave on my trip sometime Sunday or Monday morning.