I think what you need to focus on is whether you want a triple or a compact crank. Like many have stated a full sized crank is more for a racing bike. The bikes you've mentioned are relaxed geo road bikes. Unless you're very fast the larger crank is wasteful. Let's say you're running 20 mph. That's too fast for most of us in the small chainring. With a 53 big chainring you'll be in a bigger sprocket in back and your chain will not be running as straight back as with a 50. A twisted chain (cross chained) will waste energy. So even with the same cadence it takes more effort to go 20 mph.