I don't know anything but BB riding.i've been on them for 10 years since the Heart attack.However my low blood pressure is attributed to riding mostly.Before I started seriously riding about 16 months ago with the pills my bb was like 140/92 now it's like 120/70 and less.I also lost 22 lbs.I'm curious what riding would be like without them.The Doc isn't.I can say I ride at a different level than what I started with a century under my belt and of course much stronger in every way.