Hmmm...my calves are usually sore after a ride, but not during. Dont feel anything at ALL in my glutes, but I do feel it mostly in my quads. Saddle is all of the way down. when the guy at the bike store set me up, he made sure that my foot was on the pedal with a slight bend in my knees when it was at the bottom. He also wanted me to be on the balls of my foot, but i find myself pushing more with my toes for some reason.
I wish I had the money to get fitted like I am supposed to be.