At the risk of pointing out the obvious, it also really depends on how well your frame is sized to you. If you are compensating for a too long or too short top tube with stem length, that will change the visual perception of the bar and hub alignment. Bar height plays into this as well.
But to answer your original question, on a frame that fits me the handlebar generally blocks the hub when I'm on the hoods, which is where I ride mostly. If you are built proportionately it's an excellent place to start.
Get your saddle where it's comfortable (height, KOPS), then set bar height and reach. Don't use either one to compensate for the other. Allow a week or two of riding between small adjustments to allow your body to adapt and give comfort feedback.