By itself? Not even close. If you had a minimum of 5 cities that large all sharing borders, then maybe you would get to "major."

Where I live, the center city has a population of 150,000, but that at least doubles if you include all the contiguous surrounding towns. Each of the surrounding towns is reached by one or two bus lines that generally don't run more than once every half hour, some once every hour. It's better in the center city, depending on where you live. It's my understanding that our bus system is actually pretty good for an area/population of this size. We just don't have the population density to support more than that.