Gator Skins, Marathon Supremes, etc... with the tires that don't have insane protection belts the big pieces of debris WILL stop you. After hearing great things about Supremes I swapped out Vittoria Randonneurs (which have been generally bulletproof) on my winter/commuter, and proceeded to get 3 flats going 4 miles. Generally flat-free ever since though.

I think the only real 'definitive' solutions are things like Marathon Pluses and Durano Pluses... I'm going to try the latter on my road bike to see if they're fit for speedy long-distance riding.