One of my riding partners rides on Gatorskins. While not bombproof, they are a good blend of performance and durability. He has had flats due to radial tire wire and sand burr stickers. My Vittoria Randonneur have withstood sand burr stickers, due to the thicker rubber, but I caught the stickers quickly and pulled them out. I doubt my Randonneurs would be able to withstand radial tire wire. The Gatorskins have a sportier feel and seem a little faster than my Randonneurs, while my Randos seem to absorb the bumps better.

The object, I suppose, is to find the tire that works best in your situation, as there is no perfect tire that will fit everyone's needs.