Here's my question: What's the long-term SAFEST way of transporting a laptop?

I have 2 bikes, and the one set up with a large Zimbale saddlebag seems like the safest. IF I were to crash, or fall, there shouldn't be too much of an impact on the bag itself and it's ability to sway a bit out to soften the blow to laptop. I've tried backpacks/messenger bags, but I'm worried that one crash could wipe out my expensive Macbook Pro if I were to land on my back. My 2nd bike has a pannier setup that seems pretty safe (low to the ground and all) but I heard that vibrations from the bike shorten a laptop's lifespan (is that even true??).

Did anyone pick one of these three systems and end up regretting it?