I've always run 25s on my roadies, with one exception.

When I put the Crud RoadRacer fenders on the Litespeed for the winter, there isn't adequate clearance on the front for the 25. I put on a 23 of the same make and model, then adjust pressure accordingly. (See: PSI Rx)

I've found there's a definite difference in both ride and handling between the 23 and the 25. I strongly prefer the 25.