I've been taking 2 squirts in each nostril every day of one steroidal nose spray or another for over 20 years. The only side effect I have noticed is the ability to breathe despite the allergen infested air of central Georgia and the allergies I inherited from my dear Mother. Flonase has been the most effective version and is what I currently use, along with a generic version of Zyrtec. I also flush my sinuses with saline every morning. Without this regimen, I don't breathe so well.