i'm not sure i understand what you mean when you say "rough"? two things came to my mind. either that there is or are a few stiff links, in which case, lube or some just bending of the links will free them up, unless you have something like a burr caught in a joint. The other thing that came to mind if the roughness was from rubbing in the derailleur either front or rear. if that's the case, then adjusting the derailleur should address that. if that doesn't do it, you may have a bent derailleur hanger.
those are the top things that came to my mind.