My wife's favorite saddle is a Fizik Arione. The position of the saddle, both for/aft and tilt, have been crucial, with just millimeters making all the difference.
Before the Arione she liked a B17, and preferred it over a B17s.

I've found that for me that an Adamo, though hideously ugly, is near impossible to beat. With that thought in mind I put one on my wife's bike thinking she could enjoy the bliss I've come to know.

Not quite. She nearly divorced me...thought I was trying to kill her or something.
I switched saddles back for her mid-ride. That's right, previous experience had taught me things could get ugly if she didn't like the Adamo, so I brought the Arione along.