My wife's favorite saddle is a Fizik Arione. The position of the saddle, both for/aft and tilt, have been crucial, with just millimeters making all the difference.
Before the Arione she liked a B17, and preferred it over a B17s.

I've found that for me that an Adamo, though hideously ugly, is near impossible to beat. With that thought in mind I put one on my wife's bike thinking she could enjoy the bliss I've come to know.

Not quite. She nearly divorced me...thought I was trying to kill her or something.
I switched saddles back for her mid-ride. That's right, previous experience had taught me things could get ugly if she didn't like the Adamo, so I brought the Arione along.

My girl is happy with the Turbo on her favorite bike. Could be a lady's model; it certainly looks shorter than my Turbo's.

Mrs Road Fan likes her men's sized B-17 Imperial. She won't let me "improve" her saddle position any more.

Somehow this made me giggle.

But, I do agree that the S versions of the Brooks saddle should work a lot better than the softer over-padded plastics. Does anitomica make a women specific saddle?

Most likely a Speed SHE.
My daughter rides one on he Shogun.

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Speaking as a lady, this weekend I just finished 150 miles in 2 days on this: https://www.avenirusa.com/parts-and-a...wh-sl-lbl.html

I bought it on clearance over a year ago for my 1984 Nishiki Century mixte, mainly because it was a women's saddle and it was white to match my bar tape. I lucked out. It is violently comfortable and I have zero difficulty with long rides. My other favorite saddle is a Selle Anatomica Titanico which resides on my 1974 Peugeot UO-18. The cutout relieves pressure on my bits and required almost no "break-in" period. I will say that for women's saddles, overall booty size is not so much the factor as it's the shape of your sit-bones. You can go get your tuch modeled at a local bike shop and then look for saddles that will offer optimal support for you based on that.

Also I've found that pretty much any saddle is ok for rides of 20 miles or less as long as it's not a completely awful saddle that nobody in their right mind should be perched on anyways. Another trick I learned, and I did this with the Nishiki, is I found myself readjusting constantly in the saddle, scooting backwards because I kept moving forwards in the saddle and finding myself hanging out on the nose rather than square in the seat. I had already moved the saddle rails as far forward as they could go, so I reversed the clamp on the seatpost to give me a few extra centimeters to move the saddle forward more, and it made a huge difference.

I do not typically use padded shorts. I did for the 150 ride but that was the first time ever. I'm about 5'5", 130lbs with a small-medium bone frame.