Sorry guys I'm just a youngster as I'm only just about to turn 50 but I do have cacked knees with not much synovial fluid from a blood disorder.......
Very rough rule of thumb is that pain in front of knee, raise seat, pain in back of knee , lower seat. Of course then you have to look at back/forward/angle adjustment too.
It's taken me about a month to get my new saddle just right. At one time I had pain in my left knee but my right knee was fine. So I took the seat up and then the pain just migrated to my right knee so just taking it down a little bit helped sort that out. I've just been micro adjusting it every time I ride and find an "issue".
A micro-adjust up or down or forward or back or angle can make all the difference