On SPDs I back off to the lightest setting and then tighten by just a turn or two before even using them. This is usually too light of retention so I tighten each a half turn at a time until there are no accidental clip outs and they feel good. I've never had to readjust after dialing them in the first time. Finding the right cleat position can take a little trial and error but shouldn't take more than a couple of rides to figure out where they feel best. I've never used Quattros or BeBops and I'm sure they are excellent pedals, but I like having some adjustment. I run very light retention on my road bike but like a bit more on my gravel grinder and MTB where I tend to encounter rougher surfaces and do more bunny hopping. I'm still well under the factory setting even on my MTB.