One thing that hasn't been mentioned...
I have found that for me it works best to get the flying out of the way at the beginning of the trip. It is easier to plan an exact date and time at the beginning of the trip than at the end. That way you have a bit of flexibility in the ride schedule and it will be less hassle if you get a day or more ahead of or behind schedule. So if I lived in Reno I'd strongly consider starting in the East.