Occasionally I train at high load/low cadence for short intervals to build strength for those times when you end up in the wrong gear for whatever reason and need to muscle it out for a bit. An example would be allowing my cadence to fall to around 60 rpm at the top of a hill repeat rather than shifting down one more time, or hammering at 80 rpm into a headwind for a few minutes before shifting. Too much of this, too soon can cause connective tissue and joint damage, but integrating incremental increases of high load/low cadence drills into your routine can strengthen those tissues and fortify your joints against injury.