Yep, cardiac meds can be hard on performance. I was on statins and a beta blocker, as well as my anticoagulants, following my two heart attacks a year apart. The beta blocker went first as it caused me to have dizzy spells when standing up too quickly or lifting anything heavy (I'm a paramedic so that wouldn't fly). Over time I found that the statins caused cognitive issues as well as weakness and muscle loss. The pain wasn't bad compared to many of the stories your hear, but I just felt "OLD". My lipid numbers were excellent (according to my cardiologist) but I felt like crap mentally and physically, to the point that I thought I'd have to quit my job. Over about 18 months I gained 25 pounds and started showing signs of depression.

After trying different meds, doses and dosing regimens without improvement, the statins went by the wayside as well in favor of Niacin. I almost immediately felt better both mentally and physically. My memory and focus improved and I started to gain stamina and put on some of the muscle I lost. In six months the added 25 pounds are gone and my physical performance is back to pre-heart attack levels and improving. My lipid numbers aren't great but my HDL is good and my LDL and triglycerides are borderline (compared to a lifetime of being quite high).