Yes you can. They have cranksets with 38, 40, 42, 44, 46, 48, 50, 52 and 54 and a 10-42t cassette.

48/10 combo is 126 gear inches which is the same as 53/11. 48/42 is 30 gear inches, 50/32 is 41 inches. So if you have 48t crank and 10-42t you will have a wider range than any other double/compact crank set up available.

The other option is get a frame that is suited for the riding you plan on using it for