Hi Nemo,
Riding position is one thing that I would be worried about switching to a pure road bike -vs- the 7500 hybrid that I am currently riding. I have had problems with neck/shoulder pain that I ended up seeing a chiro about (on the recommendation of an office mate - worked out very well). Right now I have the bar tilt on the 7500 adjusted up as high as it will go. I'm planning on gradually lowing the height on it until I achieve a position that is as close as possible to a pure road bike position.
--g