I'm rehabbing from being hit and run over last year, and I had many herniated and degenerating discs and other skeletal, tendon, and joint issues before that even happened. I have displaced bones that the surgeons decided to leave where they are, and I'm still suffering from some paralyses. I ended up in a convalescent hospital for some time. Now I say all that to tell you about a few things that have really helped me out, and made it so that I can at least ride a bicycle.

First and foremost is "bike fit". If your fit is not right, nothing else you do will work like it should. So bike fit is number one. Once you have that right, make sure the bike is properly geared for your needs and your body. With those two required items completed, I'd suggest getting this particular suspension seat-post I'm linking you to below. This, along with the seat I'm using along with it, has made a huge difference for me.

I tried about 8 or so different seats. I finally settled on this one as the most ergonomically correct for me, including for my man-parts. There is also a wider version available if that's what you need.
Selle Royal - Men's Respiro Moderate

I also installed this suspension seat-post, and I can tell you this combination has been amazing for me. The seat practically disappears beneath you, and it literally feels like you're riding on air, with absolutely zero hot-spots or pressure points at all. All jarring and impacts to my spine have been virtually eliminated. Discomfort simply no-longer exists with this setup for me.
Suntour - NCX P12 Suspension Seat-post

I hope this helps.