heart rate and/or power is a good tool for tests like that.
When it's go fast time, I use my Venge Expert with carbon wheels, an Evade and Bontrager carbon aero road bars.
But I prefer to ride my TCR Advanced with an alloy wheelset (Hed Belgium/DT Swiss/Ptap), different drop bars and lightweight road helmet - much more comfortable.
All I know is that setup #1 is definitely faster during a hot lap around Fiesta Island (4.1 mi.) at a given power.
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"Your beauty is an aeroplane;
so high, my heart cannot bear the strain." -A.C. Jobim, Triste