Yeah I know its not the end of the world to have to tighten your thru axle every 50 miles or so, but once I forgot it cocked the wheel and unscrewed the nut holding my cassette on the wheel...so I check it and tighten it every ride if needed. Do all you mountain bike folks do this? Ive tried using my nut driver to tighten it via the nut/screw on the axel, but it keeps loosening up? Anyone got a fix for it?

Many thanks, due to the advice here I have over 3000 flat free miles on my Raleigh Lore--thanks folks!!