Agree with Alan S on ease of shifting. My last tour was five weeks in the Canadian Maritimes, most of that was Nova Scotia. And it was all up and down. Not much was really steep, but it was very frequent shifting. Often I was up shifting or down shifting a couple of gears at once and that is quite easy with the twist grip shifter.

My shifter is on the right bar end, using the hubbub adapter, see photo. (Sorry, not a Troll photo in a thread on Trolls, but this is the easiest way to show my shifter location.) Since three of my derailleur bikes have bar end shifters and I have been using bar end shifters for decades, I find it quite natural to have my Rohloff shifter located at the bar end.