Had a set of wheels built-up for commuting on somewhat-rougher urban pavements. Velocity Dyad, DT Swiss spokes/nipples, Continental Tour Ride 47-622 tires, on Shimano Deore XT 36H hubs. Very capable for handling the occasional pothole, lots of seams and upheaved sections, and with the tires it's plenty able to deal with light mud, gravel, sand, and other off-pavement junk. Not the lightest setup around, but quality and durable. Tires I selected exceeded Velocity's recommendation for tire sizes, though they have worked fine. Quite impressed, overall.

If I were to do it again with the same width of tires as the goal, I'd likely select the Velocity Cliffhanger rim over the Dyad.