In addition to what bmwjoe said, combining odd and even toothed cogs and chainrings gives you more skid patches if thats something that you get up to. So if you like to stick around 85 gear inches then I'd say 48/15 is better than 52/16.
If you use brakes then I think its actually the opposite (?). I think even toothed setups put more even stresses on the chain (or something like that, somebody help me out here).
In any case it shouldnt make a huge difference in practice.
Also yeah, 85 is uncomfortably high of you ask me. Maybe I'm just a wimp though
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