You can pair an Eagle AXS RD with eTap AXS shifters for a 1x set up. This requires the use of the Eagle 12-speed chain, not the road “flat top” 12-speed chain, and an XD freehub for the SRAM 12-speed cassette. Not sure, but maybe you could run the Eagle RD and chain with a Shimano 12 speed cassette, but this would require their new Microspline freehub. Sunrace makes a 11-50 cassette that can be used on the old 11-speed freehub.

You cannot run an Eagle AXS RD and eTap AXS FD together, to the best of my knowledge.

SRAM just released a “wide” Force AXS gruppo that will let you run a 10-36 cassette in the back with a 43/30 crankset up front for a pretty big gear spread.