If you get a size that is within what the manufacturer sizing guide show, whether the bigger or smaller of the overlap size, then there are adjustments that can be made to deal with issues of too much pressure on wrists and many other pains, soreness and numbness people gripe about.

A lot can be done by just changing the fore/aft, tilt and height of the seat. Some the height of the bars. And even a change of the stem length in some cases which is the only one that will cost a few more bucks.