a pic would help.is the wheel square in the dropouts so as to not allow the small cassette sprocket to be too close the the chainstay? the chain properly routed through the rear derailleur pulley's? new crank have the proper distance from the chainstay so the chain isn't making contact to the frame? "Road Double 43.5 mm Shimano spec, measured to the midpoint between the rings.
with typical 5 mm chainring spacing, this puts the inner at 41 mm, the outer at 46 mm."https://www.sheldonbrown.com/chainline.html