The most practical way to use axs 12 speed is to stay in the big chain ring as long as possible, then shift to the little ring and usually two sprockets smaller to continue the progression to lower gears for climbing. If you do that there are really only 15 distinctly different gear ratios. The rest are duplicates or near duplicates, so you have 15 easy to find gear ratios. It really doesn't matter is the big/big is used or not. I may use it briefly, but I'm more likely to get out of the saddle instead. As an example, my 48/28 is a 1.71/1 ratio. If I shift to the 31T little ring, I then shift to the 21 and have the next lowest ratio of 1.47, plus 3 lower ratios. My lowest ratio in the big ring is a 48/33 which is just a near duplicate of 31/21.

Roller coaster roads are always a pain. I have none of that, so I may make a chainring shift only 4 times on a 50 mile ride. I never use sram sequential or compensating modes. IMO, they're for beginners or riders who don't want to learn simple shift patterns. I limit my shifts to only two if I hold a shifter lever for a multishift.

Another thing I do quite often is start a climb standing in the big ring then sit and shift to the little ring with no compensating shifts required. In my experience, pedaling standing gives me about the same amount of extra torque as a two sprocket down shift.