Originally Posted by
Iride01
However if it's 2x or 3x, I'd encourage you to never use the big big combos since there are close to the same ratios with another combination of middle or small front ring and the rear sprockets that will keep your chain line straighter. If it's a e-bike, I'd further encourage you not to accelerate from a stop in a high ratio gear. Even if the motor seems to handle it. That is just putting undue strain on the chain.
First part of the above quote just discards the last couple of decades of bicycle drivetrain development: the Holy Grail of big-big. The entire drivetrain design in 2000s was focused on one single purpose: enabling big-big and what comes with it, e.g. reduced sifting, increased efficiency, reduced chainring-sprocket wear, reduced chain strain.
Second part of the above quote actually contradicts the first: all other thigs being equal it is specifically big-big that puts less strain on the chain (than the equivalent small-
biggersmaller combination).