Gawd, whatever you do, don't buy Ksyriums, every ****** has them. They're not light, they're not aero, so why bother? My next set of wheels will most likely be Soul-Kozak hubs, Sapim CXRay spokes laced X3, and either DTRR1.1 or IRD Cadence Aero rims. Same price or cheaper than Ksyriums, more aero, and about 200g lighter.
Check out these hubs, they're insane. 243g.....a PAIR. >
Now Saccy, I think you're forgetting your bike is a Giant, and also don't forget that what you think is frame flex is 90% of the time all the parts hanging off the frame flexing. Flex also isn't necessarily a bad thing either - flex is what stops things from breaking. It's why tall buildings have built in sway.