I have lots of wheels with no eyelets and single walled rims, and they all seem to be doing fine. Granted, I'm not touring across the USA on them, but for my use, no problems. Actually, the one wheel that's been the biggest problem is a Mavic Open Pro that been breaking spokes like crazy. All of the breaks have been at the spoke nipples. I'm 170 lbs (a bit less than bigbossman's 2,000), so I have to figure there's some problem with that wheel.
Neal