Ken, yes, I've tried many adjustments: six stems, two, and soon to be three bars, tilting and sliding the seat all different ways, three different grips. I'm actually going to go back and retry some of what I've tried. Maybe the problem lies with me. Maybe my posture on the bike is poor.
The bike is a hybrid that is very, very close to a mountain bike. I've been able to ride it out in the woods without much trouble. But on roads I seem to run into hand and wrist pain after only a few miles (as in 2-3 miles).
I'd love to sit and talk to the guy at Specialized who designed the bike's frame, but that'll never happen. I find it interesting, for example, that the frame size is larger (18" versus 17") than that of my all-mountain bike, but that the effective top-tube is actually less. Adding a longer stem feels wrong. I've tried it. I actually "feel" more stretched out on the 18" bike than on the 17" bike, and that's despite the shorter effective top-tube, and the measurably shorter distance from saddle to bars.
I'm going to revisit my previous experiments. Possibly I blew through some stem and bar combinations without giving them enough of a try.