Even considering weight and bearing quality, there won't be a significant performance difference from 2200 to Dura Ace.

The 2200, Sora and Tiagra hubs are all very rudimentary. Very little cosmetic finishing and no sealing or shielding of the bearings at all. Grease will be ooze out around the cones, though this is not a problem at all, the oozed out grease offers some protection from water and dirt.

105 hubs have labrynth seals which are part of the cone assemblies. They also have internal seals to keep grease from going into the hollow middle part of the hub. Ultegra hubs are the same with better cones and races.

Dura Ace hubs use oversized axels, use 3/16 inch stainless steel bearings front and rear, have a titanium freehub body with more ratchet points and are made from better aluminum. Also, the non-lever side of the skewers are polished aluminum with a steel insert, instead of plastic with an insert on the lower groups. Which is why I only use dura ace hubs. Even on crappy bikes. I'd never want to be accused of using crappy skewers.