My route in to work is different than my route home.
Riding in, I go down Route 5 from South Windsor to East Hartford, to then head over the river into Hartford. At the early times I'm riding in there traffic is very light so I'm not worried about being on a busy state route.
Riding home I have a route that's a mile longer, but it keeps me on less busy roads. That route is different both through Hartford and on through East Hartford/South Windsor.
I agree with the various comments about safety being a prime concern. In Connecticut, where folks just aren't used to seeing cyclo-commuters, safety is certainly important to me.