Originally Posted by Kristofferson
If you wanted super comfortability you could buy a gel seat, then put a gel seat covers over the seat itself.
I see where you're going with this... put as much weight as possible on the butt and off the hands and feet since Greg has ankle and wrist issues. However, with all that "padding", he'll probably wind up cutting into nerves and blood causing seriously painful numbing.
Greg, if there's a good and reputable shop near you, just fork over the extra money for quality service. Tell them your problems and needs and let them help you buy the right bike, then fit it for YOU. You'll want the bike adjusted in such a way that you'll put the weight on your bottom, but they'll (hopefully) help you choose the right saddle and shorts so that your butt is positioned correctly on a semi-firm saddle... don't want that numbing effect.
Did/do you study Aikido/Aiki-jutsu? I could easily imagine why you have wrist issues if you did.