If you live in a relatively flat area, I would recommend 46/17 (or any combo that gives you aprox. 73 GI), but that really is a personal thing. Wheels really depend on how much you want to spend. How much do you want to spend. They also depend on the aesthetics you're going for. What aesthetics are you going for (brightly colored rims? something subtle? a more classic look?)? Velocity Deep Vs laced to Formula Hubs are a favorite for those looking for bright colors (they're also quality wheels...deeps more than DPs). I run Velocity Aeroheads (lighter than Deep Vs and a little cheaper that still have a somewhat deep profile) laced to Soma Somax hubs (probably a little overpriced, but what I wanted) for a slightly more subtle looks. I guess we need to know more about your needs, preferences and situation to be able to better answer your question.