I don't do anything between commutes from home/work/home. I try not to wear the same shorts back to back days without a washing though. I also have very sensitive skin and fear that if I were to wear more than one day in a row I would have issues. So far so good. I have 4 different pairs of spandex that I cycle through the laundry/my riding week and that seems to be enough. I would never try treating my shorts at work due to fear of an adverse reactions on the way home. I figure that if they air dry and I only really need them for a ride home I should be okay.