What's better: 145 PSI With a standard tube (120 grams or so) vs 110 PSI with a lightweight tube (50-70 grams) I say this based on my almost immediate blowouts tying to use 145 psi with a michelin ultralight tube (70gm) and a Vittoria tire capable of holding 145 psi. Some factors would be rolling resistance vs weight of the wheel, the rider's own bodyweight, and cornering. I weigh 130 lbs so I favor the lighter weight/lower pressure. Yes I know there are sew-ups, but I am not using them anymore.

What's the point to 145psi and a 130 pound rider anyway? Someone smoking too much carpet?

Better for what and for whom? Super high pressures might be good for indoor track racing, but they don't make much sense for most road racing.

130lb rider + 145psi tires = a short cut to impotency

Maybe try something more reasonable, like a 100 gram Continental tube, and 120 psi? I weigh 165-169 and ride on 115-120 psi, it feels more than harsh enough. I can't imagine weighing 30lbs less and riding on 145 psi.