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Hmb revisited

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Hmb revisited

Old 01-16-23, 08:21 AM
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Hmb revisited

A few months ago there was discussion on the possible benefits of HMB. I have been using it at about 3 grams per day, and I believe I have noticed some beneficial effects for this 83yo, mostly as increased energy. However, too many variables in my life to definitely tie down one change in supplements as a cause. Anyone else have any definable results?
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Old 01-16-23, 10:37 AM
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I'm the OP on the original HBM thread. "Definable"? As in numerical? No. But as in noticeable? Yes. If I take a gram about 30' before and after every workout, I experience muscular recovery at about the same rate as 10-15 years ago. IOW, I use the same workout volume on the bike and in the gym that I used then. That's huge. Muscularly, I'm actually stronger that I was back then. Aerobically, not the same good results. Age has continued to cut into my aerobic ability. That's a lot more complicated than muscle recovery. Still, it's really nice that the pedals feel light and I can ride as often as I want.

I also take 1 gram with breakfast and dinner, just for good measure, but I don't think those grams have the same effect at those close to workouts.
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Old 01-16-23, 03:29 PM
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Originally Posted by Carbonfiberboy View Post
I'm the OP on the original HBM thread. "Definable"? As in numerical? No. But as in noticeable? Yes. If I take a gram about 30' before and after every workout, I experience muscular recovery at about the same rate as 10-15 years ago. IOW, I use the same workout volume on the bike and in the gym that I used then. That's huge. Muscularly, I'm actually stronger that I was back then. Aerobically, not the same good results. Age has continued to cut into my aerobic ability. That's a lot more complicated than muscle recovery. Still, it's really nice that the pedals feel light and I can ride as often as I want.

I also take 1 gram with breakfast and dinner, just for good measure, but I don't think those grams have the same effect at those close to workouts.
I've been having some most uncommon prostate problems. I just don't have those. A little research shows that hmb is associated with an increase in the prostate. I'm going to stop my trial usage and see what happens. I'm a one man guinea pig..
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Old 01-17-23, 08:50 AM
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Originally Posted by gobicycling View Post
A little research shows that hmb is associated with an increase in the prostate.
Where'd you see that?
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Old 01-17-23, 12:59 PM
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Originally Posted by MoAlpha View Post
Where'd you see that?
https://www.intjmorphol.com/wp-conten...art_13_361.pdf

Efecto del Entrenamiento Concomitante y Suplementacin con β-Hidroxi-β-Metilbutirato (HMB) en la Prstata: Alteraciones en el Receptor de Andrgenos y la Inflamacin Danilo Bianchini Baptista1 ; Luis Felipe Dutra de Santana1 ; Allice Santos Cruz Veras1 ; Vernica Alves de Menezes1 ; Nilton Jos dos Santos2 ; Marcelo Papoti3 ; Jos Carlos Silva Camargo Filho4 & Giovana Rampazzo Teixeira1 BAPTISTA, D. B.; DUTRA DE SANTANA, L. F.; VERAS, C. A. S. ; ALVES DE MENEZES, V.; DOS SANTOS, N. J.; PAPOTI, M.; CAMARGO FILHO, J. C. S. & TEIXEIRA, G. R. Effect of concurrent training and supplementation with β-hydroxy-βmethylbutyirate (HMB) on the prostate: alterations in the androgen receptor and inflammation. Int. J. Morphol., 36(1):74-79, 2018. SUMMARY: Supplementation is a strategy to potentiate physical training through hypertrophy of skeletal muscles, but other tissues such as the prostate may also be affected. Changes in prostate size and function are associated with the behavior of individuals, but evidence for an association with supplementation is scarce. Therefore, the aim of our study was to evaluate the effect of b-hydroxy bmethylbutyrate (HMB) supplementation and concurrent training on the prostate. Wistar rats were divided randomly into four groups with 10 animals each: control group (C), supplemented group (S), training group (T), and supplemented plus training group (TS). The supplemented groups (S and TS) received 76 mgkg/day of HMB and the concurrent training groups (T and TS) performed exercise three times per week for eight weeks. HMB increased body composition, total weight of the prostate, and altered the histology of prostatic compartments. The lateral prostate of animals in the supplemented group had an increase in mast cells per mm2 (28.0 3.9) compared to the control and exercise group (6.1 3.0; 2.3 0.9) There was also an increase in inflammation in the stroma and lumen of the prostate, and increased expression of androgen receptor (AR) in the supplemented and trained supplemented group (79.8 2.1; 76.8 11.4) in relation to the trained group (61.5 7.0). We concluded that HMB alters hormone receptors that induce morphological changes and inflammation, and animals in the concurrent training group had normal inflammatory and hormonal profiles, and favorable prostatic histology.
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Old 01-18-23, 10:35 AM
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Originally Posted by MoAlpha View Post
Where'd you see that?
That study was of Wistar rats:
https://janvier-labs.com/en/fiche_produit/wistar_rat/
Its longevity and high rate of spontaneous tumours make it an ideal choice for ageing studies.
and hence it is frequently used for studies of prostate cancer:
https://pubmed.ncbi.nlm.nih.gov/1289678/

OTOH, HMB is used in the treatment of men with prostate cancer who are on androgen deprivation therapy:
https://ascopubs.org/doi/abs/10.1200...36.6_suppl.258

I couldn't find any human studies of the effect of HMB on a healthy prostate, though there are many websites which discuss the use of HMB by humans:
https://www.mskcc.org/cancer-care/in...cine/herbs/hmb
https://www.healthline.com/nutrition/hmb#benefits

I've been using HMB daily since. November of '21 and haven't noticed any increase in nocturnal pee frequency or anything else other than much improved muscle recovery.
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Old 01-18-23, 11:20 AM
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Originally Posted by Carbonfiberboy View Post
That study was of Wistar rats:
https://janvier-labs.com/en/fiche_produit/wistar_rat/

and hence it is frequently used for studies of prostate cancer:
https://pubmed.ncbi.nlm.nih.gov/1289678/

OTOH, HMB is used in the treatment of men with prostate cancer who are on androgen deprivation therapy:
https://ascopubs.org/doi/abs/10.1200...36.6_suppl.258

I couldn't find any human studies of the effect of HMB on a healthy prostate, though there are many websites which discuss the use of HMB by humans:
https://www.mskcc.org/cancer-care/in...cine/herbs/hmb
https://www.healthline.com/nutrition/hmb#benefits

I've been using HMB daily since. November of '21 and haven't noticed any increase in nocturnal pee frequency or anything else other than much improved muscle recovery.
I couldnt download the HMB paper, but it had no discernible mechanistic hypothesis, leading the journal editor in me to suspect an incidental finding reported with a post-hoc motivating question, and it was published in a small, regional journal. All in all, not worried at this point.
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Old 01-18-23, 01:05 PM
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Originally Posted by MoAlpha View Post
I couldnt download the HMB paper, but it had no discernible mechanistic hypothesis, leading the journal editor in me to suspect an incidental finding reported with a post-hoc motivating question, and it was published in a small, regional journal. All in all, not worried at this point.
Well I stopped the HMB for several days and my prostate has much improved. Chance? Coincidence? Who knows. The benefit I possibly received is not worth the chance I might be taking. I lived for 83 years without supplementing hmb, I'll make it a few more.
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Old 02-04-23, 11:16 PM
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Originally Posted by gobicycling View Post
Well I stopped the HMB for several days and my prostate has much improved. Chance? Coincidence? Who knows. The benefit I possibly received is not worth the chance I might be taking. I lived for 83 years without supplementing hmb, I'll make it a few more.
Its not a coincidence at all. I too suffer (too strong a word) um. Experience an enlarged prostate and noted with adding just two grams of HMB daily increased my difficulty in urination. After reading gobis post I decided to see if it was me or the HMB, so I gave up HMB three days ago and my increased difficulty has pretty much resolved. I do take a daily medication Tamusolin, to help but didnt want to up the dosage to have one drug combatting the other, since Tamusolin already lowers my blood pressure and sometimes makes me light headed when I get up too quickly. So a sad farewell to HMB and we shall see about muscle soreness and energy.

Thanks gobi for posting.
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Old 02-05-23, 07:44 AM
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I had posted my experience in the original thread and stand by my N = 1 experience.

It did not improve my aerobic capacity (as expected) but had a measurable increase in 5-10 second power levels and also in so-called functional reserve capacity or what is called W' in Goldencheetah.

Interestingly, I ran out of HMB but also got Covid with some challenges in recovery. All my numbers are lower. It seems about time to buy some more HMB.

From memory (too lazy to go find the old power files on my old laptop), peak power increased from 950 ish watts to 1150 ish watts. My 1 minute power increased from very roughly 500 to 600 watts (maybe a touch lower...I forget exactly but something like that) and 5 minute power from 340 to 375 watts. Of course, some of this is training. The peak power came up very quickly (several weeks). My aerobic or LT1 power saw no change.
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Old 02-10-23, 10:38 PM
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Am so impressed by some of our members power numbers. I don’t have a power meter but use Zwift’s Watts/Kg and found my FTP using the 20 minute ramp test (230) Using this calculator, I fall at 27% of the cycling population, meaning 73% have a higher FTP: https://www.cyclinganalytics.com/blo...output-compare. But then I am far from 50 and a couple of years away from knocking on 70. There’s my consolation.
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Last edited by rsbob; 02-11-23 at 12:08 AM.
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